CRISPRware Signals a New Era in Democratized Gene Editing
In early 2025, a quiet revolution in gene editing arrived via a piece of software called CRISPRware. Developed at UC Santa Cruz and released as open-source, CRISPRware is designed to let scientists anywhere generate entire libraries of CRISPR guide RNAs (gRNAs) for virtually any gene or genome. Importantly, it isn’t locked behind a paywall or a proprietary platform – it’s freely available and even integrated into the widely used UCSC Genome Browser, meaning that with a few clicks, researchers can visualize and select optimized CRISPR target sites across the genomes of multiple organisms.
